Video abstract of review paper “A critical appraisal of paliperidone long-acting injection in the treatment of schizoaffective disorder” published in the open access journal Therapeutics and Clinical Risk Management by authors Chue and Chue. Abstract: Schizoaffective disorder (SCA) is a chronic and disabling mental illness that presents with mixed symptoms of schizophrenia and affective disorders. SCA is recognized as a discrete disorder, but with greater heterogeneity and symptom overlap, leading to difficulty and delay in diagnosis. Although the overall prognosis is intermediate between schizophrenia and mood disorders, SCA is associated with higher rates of suicide and hospitalization than schizophrenia. No treatment guidelines exist for SCA, and treatment is frequently complex, involving off-label use and polypharmacy (typically combinations of antipsychotics, mood stabilizers, and antidepressants). Oral paliperidone extended-release was the first agent to be approved for the treatment of SCA. As in schizophrenia and bipolar disorder, adherence to oral medications is poor, further contributing to suboptimal outcomes. The use of an antipsychotic in a long-acting injection (LAI) addresses adherence issues, thus potentially reducing relapse. Paliperidone palmitate represents the LAI formulation of paliperidone. In a long-term, double-blind, randomized, controlled trial of adult patients (n=334; intent-to-treat [ITT]) with SCA, paliperidone long-acting injection (PLAI) significantly delayed risk of relapse compared to placebo (hazard ratio 2.49, 95% confidence interval, 1.55–3.99; P is less than 0.001). This study demonstrated the efficacy and safety of PLAI when used as either monotherapy or adjunctive therapy for the maintenance treatment of SCA. The results are consistent with a similarly designed study conducted in patients with schizophrenia, which suggests a benefit in the long-term control of not only psychotic but also affective symptoms. No new safety signals were observed. When used in monotherapy, PLAI simplifies treatment by reducing complex pharmacotherapy and obviating the necessity for daily oral medications. PLAI is the second agent, and the first LAI, to be approved for the treatment of SCA; as an LAI formulation, there is the advantage of improved adherence and simplified treatment in the long-term management of SCA. Read the full paper here: https://www.dovepress.com/a-critical-appraisal-of-paliperidone-long-acting-injection-in-the-trea-peer-reviewed-article-TCRM
Invega Sustenna how to video shot for Janssen, Johnson & Johnson. Multi-camera studio shoot.
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Updated Deltoid IM Injection Video: https://www.youtube.com/watch?v=DBHnd3N-5Ns Deltoid injection site of an IM intramuscular shot that includes specific deltoid technique and demonstration. Learn how to give an IM intramuscular injection in the deltoid muscle for nursing students, new nurses, or other healthcare professions. Giving an injection in the deltoid muscle is very common in the health care world and is most commonly used for influenza "flu" shot vaccination. The deltoid muscle is found in the arm, right below the acromion process. I demonstrate how to find the deltoid landmarks prior to injection and how to aspirate the syringe. Subscribe: http://www.youtube.com/subscription_center?add_user=registerednursern Nursing School Supplies: http://www.registerednursern.com/the-ultimate-list-of-nursing-medical-supplies-and-items-a-new-nurse-student-nurse-needs-to-buy/ Nursing Job Search: http://www.registerednursern.com/nursing-career-help/ Visit our website RegisteredNurseRN.com for free quizzes, nursing care plans, salary information, job search, and much more: http://www.registerednursern.com Check out other Videos: https://www.youtube.com/user/RegisteredNurseRN/videos Popular Playlists: "NCLEX Study Strategies": https://www.youtube.com/playlist?list=PLQrdx7rRsKfWtwCDmLHyX2UeHofCIcgo0 "Nursing Skills Videos": https://www.youtube.com/playlist?list=PLQrdx7rRsKfUhd_qQYEbp0Eab3uUKhgKb "Nursing School Study Tips": https://www.youtube.com/playlist?list=PLQrdx7rRsKfWBO40qeDmmaMwMHJEWc9Ms "Nursing School Tips & Questions": https://www.youtube.com/playlist?list=PLQrdx7rRsKfVQok-t1X5ZMGgQr3IMBY9M "Teaching Tutorials": https://www.youtube.com/playlist?list=PLQrdx7rRsKfUkW_DpJekN_Y0lFkVNFyVF "Types of Nursing Specialties": https://www.youtube.com/playlist?list=PLQrdx7rRsKfW8dRD72gUFa5W7XdfoxArp "Healthcare Salary Information": https://www.youtube.com/playlist?list=PLQrdx7rRsKfVN0vmEP59Tx2bIaB_3Qhdh "New Nurse Tips": https://www.youtube.com/playlist?list=PLQrdx7rRsKfVTqH6LIoAD2zROuzX9GXZy "Nursing Career Help": https://www.youtube.com/playlist?list=PLQrdx7rRsKfVXjptWyvj2sx1k1587B_pj "EKG Teaching Tutorials": https://www.youtube.com/playlist?list=PLQrdx7rRsKfU-A9UTclI0tOYrNJ1N5SNt "Personality Types": https://www.youtube.com/playlist?list=PLQrdx7rRsKfU0qHnOjj2jf4Hw8aJaxbtm "Dosage & Calculations for Nurses": https://www.youtube.com/playlist?list=PLQrdx7rRsKfUYdl0TZQ0Tc2-hLlXlHNXq "Diabetes Health Managment": https://www.youtube.com/playlist?list=PLQrdx7rRsKfXtEx17D7zC1efmWIX-iIs9 http://www.registerednursern.com/intramuscular-injection-how-to-give-an-im-injection/
Video abstract of original research "Long-term tolerability of once-monthly injectable paliperidone palmitate in subjects with recently diagnosed schizophrenia" published in open access journal Neuropsychiatric Disease and Treatment by Jennifer Kern Sliwa, Cynthia A Bossie, Dong-Jing Fu, et al. Conclusion: The long-term tolerability of paliperidone palmitate was generally similar in recently diagnosed schizophrenia subjects and those with more chronic illness, with the exception of some prolactin-related measures. Read this original research and sign up to receive Neuropsychiatric Disease and Treatment here: http://www.dovepress.com/long-term-tolerability-of-once-monthly-injectable-paliperidone-palmita-peer-reviewed-article-NDT
Paliperidone Paliperidone trade name Invega, also known as 9-hydroxyrisperidone, is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications It is developed by Janssen Pharmaceutica Invega is an extended release formulation of paliperidone that uses the OROS extended release system to allow for once-daily dosing Paliperidone palmitate trade name Invega Sustenna, named Xeplion in Europe and other countries is a long-acting injectable formulation of paliperidone palmitoyl ester indicated for once-monthly injection after an initial titration period Paliperidone is used to treat mania and at lower doses as maintenance for bipolar disorder It is also used for schizophrenia and schizoaffective disorder On May 18, 2015, a new formulation of paliperidone palmitate was approved by the FDA under the brand name Invega Trinza1 It is a 3-month extended-release injectable suspension suitable for schizophrenic patients after they have been adequately treated with Invega Sustenna for at least four months2 Contents 1 Pharmacology 2 Effects 3 Adverse effects 31 Adver Paliperidone Click for more; https://www.turkaramamotoru.com/en/paliperidone-23758.html There are excerpts from wikipedia on this article and video
Midwestern University Department of Family Medicine