Physiology of Lipoproteins Cholesterol

Physiology of Lipoproteins Cholesterol

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LDL calculation

LDL calculation

Non-fasting lipid profiles: implications for lipoprotein measurement and reporting

Non-fasting lipid profiles: implications for lipoprotein measurement and reporting

Version with interactive TOC is available on http://goo.gl/xnE2Dv. Presenter: prof. Michel Langlois MD, Ph.D. Professor Langlois is Professor at Ghent University, Department of Cardiovascular Diseases and Vice-Director at the laboratory of AZ St-Jan hospital, Bruges. He is currently the President of the Belgian Atherosclerosis Society, Past-president of the Royal Belgian Society of Laboratory Medicine. He is the Chair of the EFLM-EAS Task and Finish Group on Laboratory Testing for Dyslipidemia and member of the EFLM WG-Guidelines as well as corresponding member for the EFLM WG-Cardiac Markers and WG-Congresses and Postgraduate Education. Modrator: prof. Dr. Jerzy-Roch Nofer Fasting blood samples have been the standard for measurement of triglycerides and cholesterol, despite the fact that we spend the vast majority of our time in non-fasting conditions. However, when recent studies suggest that postprandial effects do not substantially alter lipid concentrations and do not weaken, and even may strengthen, their association with cardiovascular risk, then a non-fasting blood draw has many practical advantages. Non-fasting cholesterol measurements include the ‘remnant cholesterol’ fraction, a strong risk factor for developing atherosclerosis independent of LDL cholesterol. Remnant cholesterol reflects the cholesterol in chylomicron- and VLDL-remnant particles and it is included in the ‘non-HDL cholesterol’ calculation. Until recently, most guidelines focused on targeting primarily LDL cholesterol for the prevention of cardiovascular disease, but they now recognize that non-HDL cholesterol (or apolipoprotein B, the molecule carried by all non-HDL particles) is a more accurate and comprehensive predictor of atherogenic lipoprotein-related risk. In 2016, the European Atherosclerosis Society (EAS) and EFLM Joint Consensus Panel recommended using non-fasting lipid testing for routine clinical practice and provided specific cutpoints for desirable fasting and non-fasting lipid concentrations to be reported by the laboratories uniformly. EFLM webinar recorded at 7th June 2016.

How to Reduce Bad Cholesterol

How to Reduce Bad Cholesterol

Watch more Healthy Eating videos: http://www.howcast.com/videos/432350-How-to-Reduce-Bad-Cholesterol A little attention to detail never hurt anyone and may have benefits if it involves monitoring what you put in your body. Reduce your bad cholesterol through simple disciplined measures that are proven to help. Step 1: Disrupt fat with exercise Use exercise to naturally disrupt the metabolism of fat. Eating less helps, but excess body fat will keep cholesterol up until you actually lose pounds by breaking a sweat. Moderate walking and workouts five days a week can raise good cholesterol by 10 percent. Tip The National Heart, Lung, and Blood Institute of the National Institutes of Health suggests everyone 20 and over should check their levels of bad cholesterol every five years. Step 2: Relax and reflect Relax and reflect periodically, rather than give in to the high tension that constricts arteries and raises blood pressure. If you're constantly stressing out, consider making some long-term changes that will eliminate some of your stres for good. Step 3: Get good greens Drink green tea, full of compounds that can help lower bad cholesterol. Eat leafy greens as well, for soluble fiber that sponges up cholesterol in the digestive tract. Step 4: Consume nuts Consume nuts instead of cheese, meat, or croutons in salads. According to the Food and Drug Administration, a daily handful of 42.5 grams of nuts may reduce cholesterol and the risk of heart disease. Step 5: Substitute fish Substitute meat with fish twice or three times weekly. Consuming fish can profoundly lower cholesterol and triglycerides. Step 6: Choose smart fats Select smart fats for your diet, substituting canola or olive oils for vegetable oil, butter, margarine, lard, or shortening. It's not merely fats, but the kind of fats you eat, that make the difference. Tip Eggs do not drastically increase cholesterol. Step 7: Take drugs to lower cholesterol Take a cholesterol-lowering drug if you have evident cardiovascular risks. Beforehand, consider alternatives like niacin, bile acid resins, and fibrates. Step 8: Commit to win Resolve to make changes, and live a healthy lifestyle. It's your life -- only you can make the changes to lower your bad cholesterol. Did You Know? In 2010, researchers identified nearly 100 gene variants possibly linked to as much as one third of hereditary factors influencing cholesterol production.

LDL vs HDL

LDL vs HDL

LDL vs HDL

Predicting heart attacks: researchers develops potential blood test

Predicting heart attacks: researchers develops potential blood test

DOWNLOAD HERE: http://newsdirect.nma.com.tw/SingleItem.aspx?asset_id=OEM_20120322_OINT_003 Every year numerous patients visit their doctors complaining of chest pain and are sent home because they pass the stress test, only to suffer a heart attack days later. Researchers from Scripps Translational Science Institute found that normally, circulating endothelial cells (CEC) line the inside of the coronary artery. However, days before heart attacks, the artery is inflamed. CEC cells deform, and eventually fall off to enter the bloodstream. Source: Heart Wire, Fox, LA Times

LDL & HDL by Bryana Workman & Jenna Ruiz From Lorain High School

LDL & HDL by Bryana Workman & Jenna Ruiz From Lorain High School

LDL & HDL by jenna ruiz and bryana workman from Lorain High School

3 Genes That Give People Superpowers

3 Genes That Give People Superpowers

There are genetic mutations in the population today that can grant people some seemingly superhuman abilities. To get your 23andMe kit, go to: https://www.23andme.com/SciShow Hosted by: Hank Green ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Dooblydoo thanks go to the following Patreon supporters—we couldn't make SciShow without them! Shout out to Kevin, Bealer, Mark Terrio-Cameron, KatieMarie Magnone, Patrick Merrithew, Charles Southerland, Fatima Iqbal, Sultan Alkhulaifi, Tim Curwick, Scott Satovsky Jr, Philippe von Bergen, Bella Nash, Bryce Daifuku, Chris Peters, Patrick D. Ashmore, Piya Shedden, Charles George ---------- Looking for SciShow elsewhere on the internet? Facebook: http://www.facebook.com/scishow Twitter: http://www.twitter.com/scishow Tumblr: http://scishow.tumblr.com Instagram: http://instagram.com/thescishow ---------- Sources: MSTN - stronger muscles https://blogs.scientificamerican.com/guest-blog/the-man-of-steel-myostatin-and-super-strength/ http://www.nejm.org/doi/full/10.1056/NEJMoa040933#t=article https://ghr.nlm.nih.gov/gene/MSTN#normalfunction https://www.ncbi.nlm.nih.gov/books/NBK1498/ http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300003 http://onlinelibrary.wiley.com/store/10.1113/expphysiol.2012.065243/asset/eph1073.pdf?v=1&t=j1mbvm9e&s=cc218db59ef9337ad4c1baecfb2b099fc4bef4ed https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698719/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177043/ ACTN3 - fast-twitch muscles https://www.ncbi.nlm.nih.gov/pubmed/17289854 https://www.ncbi.nlm.nih.gov/gene/89 https://www.ncbi.nlm.nih.gov/pubmed/26429734/ https://www.ncbi.nlm.nih.gov/pubmed/26148057 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150594 https://www.wired.com/2008/11/the-actn3-sports-gene-test-what-can-it-really-tell-you/ http://muscle.ucsd.edu/musintro/fiber.shtml https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180686/ http://jap.physiology.org/content/116/9/1197 LRP5 - stronger bones https://ghr.nlm.nih.gov/gene/LRP5#conditions http://www.nejm.org/doi/full/10.1056/NEJMoa013444#t=article http://www.sciencedirect.com/science/article/pii/S0002929707605941 http://www.sciencedirect.com/science/article/pii/S8756328205000165 http://onlinelibrary.wiley.com/doi/10.1359/jbmr.2003.18.6.960/full https://www.snpedia.com/index.php/Rs1815739 http://www.jbc.org/content/281/50/38276 http://oregonstate.edu/dept/biochem/hhmi/hhmiclasses/biochem/lectnoteskga/jan29.html http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063323 ---------- Images: https://commons.wikimedia.org/wiki/File:MyostatinMutantWhippet.jpg https://commons.wikimedia.org/wiki/File:Protein_ACTN3_PDB_1tjt.png https://commons.wikimedia.org/wiki/File:General_pathology;_from_the_11th_rev._German_ed._(1921)_(14578295997).jpg

HDL - LDL(trabalho)1ano .wmv

HDL - LDL(trabalho)1ano .wmv

Rethinking 'Good' Cholesterol; PSA Test Debate

Rethinking 'Good' Cholesterol; PSA Test Debate

This is the VOA Special English Health Report, from http://voaspecialenglish.com | http://facebook.com/voalearningenglish A study has raised questions about a widely held belief involving cholesterol. The belief is that high levels of so-called good cholesterol in the blood can reduce the risk of a heart attack. The medical name for "good" cholesterol is high-density lipoprotein, or HDL. Doctors commonly believe it reduces the risk of heart attack by removing fatty deposits that can block the flow of blood in the arteries of the heart. But Dr. Sekar Kathiresan at Massachusetts General Hospital in Boston says the effects of high HDL have never been proven. He says the new study that he and other researchers did suggests that HDL cholesterol does not affect the risk of heart attack. He thinks the study has now broken "the major assumption over the last thirty years, that if you raise HDL cholesterol, the risk for heart disease will be lowered."The researchers say about four percent of people have a genetic variant, a change, that gives them a naturally high level of HDL. The study found that those who were genetically "programmed" to have higher HDL levels were just as likely to suffer heart attacks as those who were not. A second analysis looked at fourteen gene variants that increase good cholesterol. Dr. Kathiresan says people with the most variants had no more protection against heart attacks than anyone else. But he says there is no dispute about low-density lipoprotein, or LDL. LDL, the so-called bad cholesterol, causes a buildup of fatty substances inside arteries and increases the risk of heart attack. The findings appear in the Lancet medical journal. Another widely held medical belief has also come into question recently. For years, men over the age of forty have been told to get a simple blood test to see if they have prostate cancer. Now, experts on a government committee are advising them not to. Dr. Virginia Moyer heads the United States Preventive Services Task Force. She says, "Close to two-thirds of older men have prostate cancer and yet the huge majority of them never have a problem from it in their lifetime." The task force examined two large studies before deciding that treating the cancer found by the PSA test can do more harm than good. Effects of the treatment can include a loss of sexual ability and bladder control, as well as other problems including heart attacks. Some doctors support the findings of the task force, but others disagree. Urologist Deepak Kapoor says in about twenty years of PSA testing, death rates for prostate cancer have dropped by thirty-eight percent. For VOA Special English, I'm Carolyn Presutti. (Adapted from a radio program broadcast 06Jun2012)

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