Corneomandibular reflex is a pathological phenomenon evident in cases of severe brainstem damage. It is considered to be a pathological exteroceptive reflex, associated with precentro bulbar tract lesions. The sign is useful in distinguishing central neurological injuries to metabolic disorders in acutely comatose patients, localizing lesions to the upper brainstem area, determining the depth of coma and its evolution, providing evidence of uncal or transtentorial herniation in acute cerebral hemisphere lesions, and it is a marker of supraspinal level impairment in amyotrophic lateral sclerosis and multiple sclerosis. This sign was evident in a patient with severe brain damage.
J Neurosci Rural Pract. 2015 Oct-Dec; 6(4): 591–593.
PMCID: PMC4692024 PMID: 26752910 Corneomandibular reflex: Anatomical basis Michele Pistacchi, Manuela Gioulis,1 Davide Mazzon,2 and Sandro Zambito Marsala1